Plotline: Wario runs out of money after falling for some Nigerian prince scams/lawsuits and loses both his castle and his totally legit microgame buisness. Then he goes to Waluigi's apartment. Waluigi gets pissed when he hears (because that means he can't leech off Wario anymore), but Wario calms him down and the two decide that one way or another, they're getting their dough back.
So they head off to Dr. Crygor's place, since he's a science guy and could probably help them. They convince Crygor to help with a promise of 1/3 of the dough (fingers crossed behind their backs, though). So after packing up their shit, the three of them move into a crackden in some random neighborhood to keep the cops off their tail, and scheme ways to get rich quick. Crygor acts as their middle man and "plug"; he spreads Wario and Waluigi's names to employers, cooks drugs for them with his SCIENCE SKILLZ and notifies them of "odd jobs" from the apartment, and most missions involve Wario and/or Waluigi taking one of those jobs (and failing hilariously) as... THE WAA-JOB CREW.
The jobs that THE WAA-JOB CREW fail at range from farming, working at fast food restaurants, and other ethical and morally sound jobs like robbing banks, robbing stores, selling/purchasing illegal drugs, hacking, hitmen for hire (generally hired by gangstas to kill other gangstas and rival gang members, or people wanting to kill an annoying coworker or something), bodyguards for pimps, counterfeiting, and MAYBE doing a legit job once in a while, but only after the get-rich quick shit. When not on the job, they earn money in the neighborhood (aka hub level) in easy ways, like placing pizza delivery orders to the crackden to mug the delivery guy, escaping the opps, and going on epic adventures. A lot of other characters from all across the Mario franchise appear in roles of varying size, often as part of a mission, except the main Mario characters.
Wario has a manly physique that allows him to break shit better, take more damage and makes him better for fighting, can save money on clothes by wearing his childhood outfits (cause he short), and has the power to instantly ruin a girl's day on sight. Waluigi is faster/more agile, is a better hacker, has epic dance skills, and can go shirtless without instantly repulsing everyone in the room. His frail, slim-jim figure lets him reach groceries from the top shelf without a stepladder, but it combined with his even worse luck compared to Wario makes him not the best for fighting and especially chance based missions. You can swap between characters at any point. Also, Co-op is available so you and a pal can fail and be deadbeats in harmony.
Do they ever get rich again? And will Mario and his friends eventually appear in some form? Well, maybe, who knows. I didn't think that far ahead.
As for the name... I got stuck on that part. You guys choose, I guess.