it seems like you've got big ideas for characters and plot, and that's cool, but overall it could use some work.
For starters, I'd practice drawing the characters more so you can free hand them, instead of using circle tool and line splice for most of their lines. The dialogue is kinda strange and doesn't read well in a few places, "mutilize" isn't a word, and I'm not sure why there's an electric fence on the roof of a skyscraper at all.
None of the characters on the cover appear in this first issue at all (those that aren't covered up by Mario and the blue guy that is), which makes me wonder who's more important in this story.
But that said, I'm sure a lot of work went into this and there'd be more potential in it if it was refined.